Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Tuesday, January 28, 2014

Rapid Alcohol Consumption and Anterograde Amnesia

Interesting. Binge drinkers who pace themselves are far less likely to experience blackouts. 

Alcohol will impair partially or completely the brain's ability to transfer short term memories created during a drinking episode to long term memory storage centers. Everyone knows this. However, the occurrence of anterograde amnesia (i.e. blackout) has little to do with the amount of alcohol consumed, but is directly related to the amount of time in which a large amount of alcohol is consumed. Studies show test subjects don't experience blackouts when drinking slowly, despite being heavily intoxicated by the end of the experiment.

Wednesday, January 22, 2014

From DoseMakesPoison Blog: 4 Synthetic Cannabinoids Will Be Placed In Schedule I

The Dose Makes The Poison: Notice of Intent - 4 Synthetic Cannabinoids Placed...On January 10, 2014, the Federal government filed its notice of intent to use its emergency scheduling powers to temporarily place four synthetic cannabinoids into Schedule I of the Controlled Substances Act (CSA) for the next two years....

Thanks to dosemakespoison.blogspot.com. All material on this blog is worth further reading.

The Clandestine-PV Legacy Continues

Some new PV-analogues have been surfacing in the US over the last few months. Little is known about their safety or toxicity profile, or about their relation to alpha-PVP in terms of SAR (structure-activity relationship).

There have been some anecdotal reports on their effects, but very few. The one exception being a collection of reports on "PV-8" scattered across various forum/message boards; most of these claim it produces little to no results and is an overall disappointment. PV-8 is the 2-carbon extended homologue of A-PVP.

A 3,4 dimethoxy analogue (i.e. 3,4-dimethoxy-a-PVP) was rumored to have surfaced late last summer, but it seems to only have been talked about briefly. It could legally be considered an analogue of MDPV by federal law and in some cases fall within schedule I. It is very similar to MDPV in its structure differing in only an opening of the dioxole ring structure of the phenyl group. Its hard to say how this chemical would compare to MDPV in other respects, and there are seemingly no first hand accounts on Di-MeO-a-PVP.

It also seems that 4-MeO-a-PVP has more recently surfaced, but as is the case with the 3,4-dimethoxy homologue, there is little to no information available on its toxicological properties, potency, or effects relative to the parent drug.

The ring fluorinated homologue (specifically, 4-fluoro-a-PVP) has appeared and, other than APVP and MDPV, may just be the only chem in the clandestine-PV line with any staying power, with reports suggesting results are similar in nature to MDPV and A-PVP, with some preferring the fluoro. As with 4-fluoroamphetamine, 4-F-PVP seems to be corrosive to tissues, causing discomfort and possible damage with some routes of experimentation.

Though pentedrone has been a known RC for a while, its methylphenyl homologue has been a more recent development in the clandestine RC world. Pentedrone itself still remains common as a designer stimulant, and although it's not a pyrrolidine based cathinone, it shares the pentyl backbone and a similar potency to PV (much stronger than methcathinone and active at less than 10mg). 4-methylpentedrone has been said to produce results close to those of the parent chem, and seems to have generated, for the most part, positive feedback. I currently have no information on its potency off-hand.

Saturday, January 18, 2014

A-F and B-F



If you don't know the actual names of these compounds then you shouldn't be going anywhere near them.

These compounds should both just be avoided altogether. I can easily see this new trend toward fent analogues ending very badly - either with mislabeled "heroin" products being distributed to unsuspecting buyers (just like 3-methylfentanyl throughout the 80's being sold as "china white" and leading to a rash of overdoses, some fatal), or with another neurotoxic impurity as was seen with MPTP (which caused a permanent state of parkinsonism in a few unlucky consumers). 

Anyone who does run across these compounds should be extremely careful, they should NEVER be used without precision measuring equipment. Both compounds are believed to lie between fentanyl and diamorphine in their potency. Always be aware of your state laws (not to mention federal law) pertaining to both. I will never condone breaking the law.

Wednesday, January 15, 2014

Links of Interest

CDC Issues Release on Desmethylfentanyl (Acetyl-Fentanyl) Related Fatalities - Anyone who runs across this chemical should be extremely careful, in fact it should NEVER be used with out a .01 or .001 scale (a scale with the capacity for ten micrograms or single micrograms). Its potency is believed to lie between between that of fentanyl and diamorphine. Also be aware of your state laws (not to mention federal law) pertaining to A-F.

A Phenomenological Study of Experiences Induced by the Arylcyclohexylamine Derivative MXE - The study suggests it to be more potent in its subjective effects than ketamine. This does not surprise me. Again, tread with caution.