Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Monday, June 3, 2013

Monoaminergics: Household Names

Common CNS stimulants and their modes of action clarified. I'll probably make additions to this list over time.

NDRI: This is an abbreviation for Norepinephrine and Dopamine Reuptake Inhibitor. NDRI's work by inhibiting the function of the dopamine and norepinephrine transporters, usually causing a subsequent increase in available synaptic dopamine and norepinephrine.

NDRA: This is an abbreviation for Norepinephrine and Dopamine Releasing Agent. NDRA's work by inhibiting the function of the dopamine and norepinephrine transporters while reversing their flow (through a process known as phosphorylation), causing the release of dopamine and norepinephrine into synaptic vescicles.
Dopamine Transporter (Source: Wikipedia)

amphetamine - NDRA, NDRI
methamphetamine - NDRA, NDRI
cathinone - NDRA, NDRI
methcathinone - NDRA, NDRI
napthylaminopropane - Triple-RA/RI, serotonergic agonist/partial agonist
cocaine - SNDRI
methylphenidate - NDRI
Naphyrone - SNDRI
prolintane - NDRI
pipradol - NDRI
bupropion - NDRI
6-APB - Triple-RA/RI, 5HT agonist
5-APB - Triple-RA/RI, 5HT agonist
MDMA - Triple-RA/RI
MDA - Triple-RA/RI, 5HT2A agonist
4-MEC - Triple-RA/RI
4-FA - Triple-RA/RI

1 comment:

  1. What are caffeine's mode of action? How about the other alkaloids present in coffee?