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Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Friday, April 12, 2013

Observations With 4-MEC, 4-FA, and 2-FMA

Based on what I've heard reported first hand and throughout the web, I've noted the following consistencies, in hopes of providing a better general understanding of each of these compounds.

2-FMA 

2-FMA seems to be very active in doses of 50 mg and up.

Provides a clean, mellow, stimulated state for a few hours

It causes a heavy, shortlived cough and a strange tickling sensation in the urinary tract when taken by more direct routes, as does its 4-desfluoro parent (methamphetamine).

Powder is clean white with a snowy appearance. Powder seems to dissolve readily and easily in water.

Reports on 2FMA being a "functional" stimulant seem to be on the mark. This seems to be a compound that the well-disciplined researcher could function adequately on during work or while performing other important duties.

4-FA 

4-FA seems to be very active in doses of 50mg and up. Oral dosing may require slightly larger amounts (I'll estimate 75mg or more). 

Product appeared as a fine snow-like powder; its color was white but compared to 2-FMA it could be considered a slight off-white.

Produces effects similar to both 2FMA and 4MEC. 

It has mild but noticeable empathogen qualities.

It produces significant mydriasis (pupil dilation), like ecstasy and 4MEC.

It causes a heavy, shortlived cough and a strange tickling sensation in the urinary tract when taken by more direct routes, as do methamphetamine and 2-FMA. Nausea is common especially with higher doses. It may be a good idea to stay near the toilet when first administering 4-FA in case of bladder dysfunction or vomiting.

This is probably not a compound to use while working or committing oneself to other important duties requiring a clear head and normal appearance.

4-MEC 

4-MEC seems to be extremely active in doses of 75 mg and up when taken by more direct routes of administration. Oral doses may require 100 mg or greater for this level of effects.

Its effects are very comparable to pure MDMA. Its stimulant properties are accompanied by empathogen properties which are equally strong if not stronger. 

The 4MEC experience could be described as a tweaky "roll"-like experience, which lasts a couple hours (typically not as long lasting as molly).

Some of the highest quality 4-MEC typically appears in the form of crystalline shards (small and large), which break into a sandy powder. This compound seems to dissolve fine in water, but not as readily or easily as the more powdery RC's (such as 2-FMA or 4-FA).

4-MEC produces an often overwhelming rush and an "instant roll" when administered by more direct routes. This is a very active chemical and should be handled/used with extra caution.

Nausea is likely and may be intense, but subsides after vomiting.

This is definitely not a compound to use while working or committing oneself to other important duties requiring a clear head and normal appearance.

Monday, April 8, 2013

Diphenylpyrrolidines

The compounds below are sometimes available as research chemicals and have been sold as designer drugs. They share structural similarities with drugs of the piperidine family such as methylphenidate and desoxypipradol, as well as N-pyrrolidinyl-cathinones such as MDPV and a-PVP. They also share some interestingly similar characteristics in their mode of action and subjective effects.

D2PM

D2PM Molecule

D2PM is a long acting stimulant which has been sold as a research chemical and designer drug. It is alternately known as diphenylprolinol.

D2PM is an NDRI with a mode of action similar to desoxypipradol and methylphenidate. 

Structurally related to pipradol and desoxypipradol, but contains a pyrrolidine ring in place of a piperidine ring. Being a chiral compound, the dextro-rotatory enantiomer [(R)-(+)] is the most pharmacologically active.

Long acting compound. Its effects generally last 5 to 8 hours.

Due to its long duration, dose accumulation may be an issue; especially when combined with its potential to produce a state of "tweaky" over-stimulation.

Noteable adverse effects include paranoia, anxiety, myoclonus, psychosis, hallucinations, delerium due to lack of sleep, and a state of prolonged agitation lasting days after use. Adverse effects with long term use may include neuro/cardio-toxicity, and physical/psychological habituation.

desoxy-D2PM

desoxy-D2PM Molecule
Desoxy-D2PM is a stimulant compound which has been sold as a research chemical and designer drug. It is
alternately known as 2-diphenylmethylpyrrolidine.

Desoxy-D2PM is an analogue of diphenylprolinol, differing only with the absence of a hydroxyl group at the carbon-2 position. It is related to diphenylprolinol in the same way that desoxypipradol is related to pipradol.

Its mode of action is similar to related compounds; desoxy-D2PM is a norepinephrine-dopamine reuptake inhibitor.

It's effects are similar to diphenylprolinol as well as desoxypipradol. 

It has been reported to possess some of the same downsides as its relative 2-DPMP; with adverse effects being characterized by agitation, anxiety, paranoia, prolonged insomnia, and compulsiveness. These characteristics are shared by its distant relatives of the N-pyrrolidinyl substituted cathinone family, specifically MDPV and a-PVP. 

Adverse effects with long term use may include neuro/cardio-toxicity, and physical/psychological habituation.