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Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Thursday, February 28, 2013

Tryptamines Portal

DMT

Known also as dimethyltryptamine. DMT is a naturally occuring psychedelic of the tryptamine family. It is present in many plants & mammals, and is available for recreational use. Chemically known as dimethyltryptamine, it is structurally related to the neurotransmitter serotonin, the hormone melatonin, and the psychedelic compound psilocybin. 

DMT products are consumed primarily for their psychedelic, hallucinogenic, or entheogenic properties. When combined with an MAOI to facilitate oral absorbtion, DMT is the main constituent in ayahuasca; a beverage consumed in Amazonian circles for entheogenic purposes.

DMT produces intense and short acting effects when smoked. Dosages commonly range from 2-60 milligrams (smoked).

Its mode of action is complex. DMT is known to act as a non selective agonist at multiple serotonergic receptors. It also interacts with dopaminergic, adrenergic, sigma, and trace amine associated (TAAR) receptors, with varying profiles of efficacy.

AMT

Also known as alpha-methyltryptamine. AMT is a synthetically produced psychedelic of the tryptamine family, also related to DMT. Its effects are relatively long lasting, and recommended dosages are slightly higher than those for DMT.

AMT produces both psychedelic and stimulant effects. In addition to its action as a non-selective 5HT receptor agonist, AMT acts as a monoamine releasing agent (that is, it induces synaptic release of dopamine, noradrenaline, and serotonin).

AMT is chemically related to tryptamine in the same way amphetamine is related to phenethylamine; with the addition of an alpha methyl group on the alkyl chain. AMT differs chemically from DMT in two ways; a) a secondary amine rather than a tertiary amine, and b) the aforementioned CH3 group at the alpha carbon.

AMT is commonly smoked or consumed orally. Its effects can take up to 2 hours to become fully apparent, and may last 12 hours or more when high doses are consumed. Nausea and vomiting has been commonly reported.

Psilocybin:

Psilocybin is a naturally occurring psychedelic compound which is present in 200 or more species of mushrooms. Psilocybin containing mushrooms are popularly known as "magic mushrooms". Magic mushrooms grow naturally in the US and elsewhere, or, may be artificially cultivated indoors.

Psilocybin is a drug of the tryptamine family, chemically related to DMT as well as the endogenous neurotransmitter, serotonin.

Psilocybin is rapidly metabolized to psilocin via dephosphorylation, with psilocin being mainly responsible for its effects. Psilocin targets the brain's serotonergic pathways, acting as an agonist at the 5HT2A receptor, as well as other subtypes, to a lesser extent.

MiPT 

Known chemically as methylisopropyltryptamine, MiPT is a psychoactive compound related to other tryptamines such as DMT and DiPT. 

It was mentioned in Alexander Shulgin's book TIHKAL.

MiPT is reported to affect auditory perception and cognition more so than visual perception.

Analogues of MiPT have been marketed as research chemicals in recent years.

DiPT

Known chemically as diisopropyltryptamine, DiPY is a psychedelic tryptamine related to both DMT and MiPT.

Users have reported marked changes in auditory perception with the experience.

Numerous analogues of DiPT have been marketed as research chemicals.

DALT

Known chemically as N,N-diallyltryptamine. DALT is a psychedelic tryptamine related to DMT, MiPT, and DiPT.

It was mentioned in Shulgin's book TIHKAL, and numerous analogues of this compound have appeared for sale as research chemicals.

4-ACO-DMT

Also known as O-acetylpsilocin. 4-ACO-DMT is a psychoactive compound of the tryptamine family. It is a ring substituted homologue of DMT, related to psilocybin and psilocin (the magic mushroom alkaloids). 4-ACO-DMT is an RC and is usually prepared synthetically, but like psilocybin, it acts as a prodrug for psilocin.

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