About

Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Friday, September 28, 2012

Aminopropylbenzofurans (i.e. Benzofuran-Substituted Aminopropanes)

5-APB: 

Known chemically as 5-(2-aminopropyl)-benzofuran. 

5-APB is an aminopropane derivative, and a drug of the substituted amphetamine family. In its pure form it produces potent empathogen and stimulant properties on par with MDA or MDMA. 5-APB has appeared in recent years as a research chemical and novelty product. .

5-APB is a ring-substituted phenethylamine, and a structural analogue of MDA, containing a benzofuran rather than a methylenedioxy ring. 

Its effects are similar to MDMA (ecstasy). Its mode of action involves monoamine systems; 5-APB is a monoamine reuptake inhibitor; it shows high affinity for the noradrenaline transporter (Ki: 180), a high affinity for the dopamine transporter (Ki: 265), and a lower affinity for the serotonin transporter (Ki: 811). 5-APB is also an agonist at the 5HT-2B (serotonergic) receptor, and may also be a monoamine releasing agent.

6-APB: 

Chemical name is 6-(2-aminopropyl)-benzofuran. 

5-APB is an aminopropane derivative, and a drug of the substituted amphetamine family. In its pure form it produces potent empathogen and stimulant properties on par with MDA or MDMA. 

6-APB has appeared in recent years as a research chemical and novelty product. It was probably best known as the active ingredient in a recreational product called "Benzo Fury", a compressed tablet form of 6-APB

5-APB is a structural analogue of MDA but contains a benzofuran rather than a methylenedioxy ring. It is closely related to 5-APB, differing only in the position of its 3,4 benzofuran ring.

Its effects are similar to MDMA (ecstasy). Its mode of action has not been confirmed, but 6-APB is believed to affect dopamine, norepinephrine, and serotonin (5HT) systems. Agonist action at multiple 5HT subtypes has also been speculated

6-APDB:

Known chemically as 6-(2-aminopropyl)-2,3-dihydrobenzofuran.

6-APDB is an empathogen & stimulant drug of the aminopropane chemical family. It was first synthesized in the 1990's by  medicinal chemist David Nichols, who at the time was studying non-neurotoxic analogues of MDMA.

Chemically, 6-APDB is the 2,3 saturated homologue of 6-APB. It contains no 2,3 double bond on the furan ring, and differs from MDA only with the presence of a methylene bridge in place of the 3-oxygen atom on the MDA molecule.

6-APDB shows a similar pharmacological profile to MDA, particularly in its effect on the serotonin reuptake transporter. It is somewhat less potent in its action on the catecholamine (dopamine-norepinephrine) reuptake transporters. In addition to its action on monoamine reuptake transporters, it has been speculated to act as monoamine a releasing agent as well.


5-APDB:

Known chemically as 5-(2-aminopropyl)-2,3-dihydrobenzofuran.

5-APDB is an empathogen & stimulant drug of the aminopropane chemical family. It was first synthesized, along with 6-APDB, by  medicinal chemist David Nichols as part of his research into non-neurotoxic MDMA analogues.

Chemically, 6-APDB is the 2,3 saturated homologue of 6-APB. It contains no 2,3 double bond on the furan ring, and differs from MDA only with the presence of a methylene bridge in place of the 3-oxygen atom on the MDA molecule.

5-APDB differs from MDMA or MDA in its effects, in that it produces strong empathogenic reactions with very little CNS stimulant activity. It is a highly selective serotonin releasing agent (or SRA).


5-MAPB: 

Known chemically as 5-methyl-aminopropylbenzene. 5-MAPB is the N-methyl analogue of 5-APB. It bears the same relation to 5-APB as MDMA does to MDA. 5-MAPB has been recently available as a research chemical and produces entactogen-stimulant reactions in doses of around 100 mg. 


2 comments:

  1. Buy at good and affordable prices: Benzodiazepines, Pain pills, Anxiety pills, Relief pills, Insomnia pills, Weight Lost pills, Stimulants, Opiate/Opioid, Marijuana, Research Chemicals, Steroids, HGH, etc.. Website: http://www.jj-chemsales.com, Email: jjm.vendor@gmail.com, Text: +1 (762) 338-1314.

    ReplyDelete
  2. sale MDPV A-PVP MDMA 2-FMA 4MMC 3MMC U-4700. Skype :omanbiot@outlook.com
    jack@omanbotech.com

    ReplyDelete