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Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Friday, March 23, 2012

Modafinil Vault

Modafinil is a psychoactive compound with CNS stimulant & analeptic properties. It has been used in the treatment of sleep disorders. It is available in the US under the trade name Provigil. Modafinil is included in schedule IV (4) of the DEA list of controlled substances; and thus considered to have "a recognized medicinal use, and a limited potential for abuse, dependence, and addiction. 

Though its pharmacology has not been well established, it is believed to act by increasing the synaptic release of catecholamine neurotransmitters such as dopamine and norepinephrine in the central nervous system - according to numerous studies. Modafinil has also been shown to activate glutamatergic excitatory neurons while suppressing the inhibitory actions of GABA circuits. It differs from amphetamine in that its wakefulness promoting actions are not completely suppressed by the administration of a dopamine antagonist.

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