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Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Sunday, March 25, 2012

Cyclobenzaprine Vault

Cyclobenzaprine is a CNS depressant with sedative, skeletal muscle relaxant, and analgesic properties. It is available for medicinal use under the trade name Flexiril. Its mechanism of action is unclear, though studies in rats have shown it to act on the locus coeruleus and promote norepinephrine-mediated inhibition of alpha motor neurons at the ventral horn of the spinal cord. These neurons mediate skeletal muscle contractions. Cyclobenzaprine is structurally very similar to tricyclic antidepressants such as amitriptyline, as well as the antihistamine cyproheptadine. 

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