About

Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Wednesday, February 15, 2012

Research Chemicals: About

Basics:

"RC's" (or "research chemicals") are quasi legal compounds sold through certain vendors and consumed for their pharmacological effects. They are, more often than not, chemical analogues of popular drugs currently controlled by federal laws. A controlled substance analogue (or CSA) is a compound derived from the same structural family as a certain illicit drug but with one or more molecular modifications, reductions, substitutions, or additions. Research chemicals are popularly known as "designer drugs", or "legal highs", and are sold in a variety of different forms, under a variety of different product names, usually labeled as non-consumable.

Legality:

In the case of our drug laws in the US, only so many certain compounds are listed specifically as controlled substances. The federal analogue act was enacted to address related compounds that are derived from, or structurally similar to, the explicitly listed controlled substances. This law allows for relatively new or obscure drugs that are not yet known, have not yet been outlawed, or have not even been discovered, to be treated as illicit drugs when they are sold and used for such purposes. This essentially allows law enforcement to keep up with the evolving drug market without having to explicitly enact a new law each time a new drug is discovered.

In order to operate within the law, or at least ambiguously within the margins of the law, RC's can not be marketed as drugs and can not be marketed as food. By marketing RC's as a variety of different non-consumable products, research tools, or novelty items, the compounds are able to avoid the regulative scrutiny of food and drug products. Such products contain clear labeling stating "not for human consumption". Such labeling allows the manufacturer and vendor to disclaim liability for potential consumer hazards (for instance, when someone swallows a powder clearly marked "drain cleaner" or "shoe shiner" and becomes ill, it's tough to argue that the manufacturer is liable). But more importantly, such marketing techniques allow the compounds to remain under the public radar and to avoid being conceptualized by law enforcement as controlled substance analogues. For instance, if the compounds were being sold as "tweak pills" or "nose powder" in the same manner that drugs like heroin and cocaine are sold, the authorities can make a strong case that the compounds are being sold and used as street drugs (as opposed to random home or novelty products with active components which just so happen to structurally resemble illicit drugs). And thus due to the context of their sale and use, along with their structural similarities with illicit drugs, can be treated as controlled substance analogues.

Safety:

Before continuing, let me emphasize first and foremost; despite being legal, easily available, and professionally packaged, these compounds are every bit as powerful and every bit as dangerous as any illicit drug. They are mere variants of the same structural families as their illicit alternatives (mutually related to the same extent as oxycodone is to morphine, diazepam is to alprazolam, etc).

As a general rule, their pharmacology exhibits no substantial difference from that of their illicit corellates. They are, generally speaking, every bit as potent and every bit as addictive.

Human consumption of these compounds often entails more risk than use of well established "street" drugs, as the RC products may have little to no history of human use, thus their effects and toxicity profiles are largely unknown. So, there is some potential for a very toxic compound to be marketed and to cause great harm or death to consumers - who basically play the role of consenting human guinea pigs by using some of these compounds.

Common RC's:

Currently there are a variety of available RC's covering a wide range of the psychopharmacological spectrum.  The most popular of the RC's fall into the stimulant, enactogen, and psychedelic/hallucinogen categories. Sedatives and anaesthetics are common as well.

The most prominent RC's are currently members of the following chemical and pharmacological families:

Substituted Phenethylamines, Phenylpropylamines, and Propiophenones (Analogues of amphetamine, methamphetamine, MDMA, cathinone, and pyrovalerone) - This category mainly consists of psychostimulants and enactogens. Some have psychedelic properties as well (2Cx and 2Cx derived compounds).

Tryptamines (Analogues of serotonin, DMT, AMT, and psilocybin)  - This group consists primarily of psychedelics, hallucinogens, or enactogens.

Piperazines (Analogues of benzylpiperazine) - This group consists of mostly psychostimulants and anorectics.

Arylcyclohexylamines/Substituted Arylcyclohexylamines (Analogues of PCP and ketamine) - This catagory consists of dissociative, anaesthetic and sedative agents.

Substituted Indoles/Naphthoylindoles (Analogues of JWH-018 - the original active constituent found in "Spice" products) - This class consists of compounds which are active at cannabinoid receptors and thus mimick the effects of cannabis products (particularly, the active cannabinoids in cannabis; such as THC and CBD)

At this particular moment, following recent bans, a few of the most prominent compounds on the market are as follows (for the sake of protecting the market, I'll use the acronyms, though I'm sure most readers can figure out the identity of the compounds from there):

4-MEC: a cathinone analogue similar to mephedrone with psychostimulant and enactogen properties

4-FA: a halogenated analogue of amphetamine with psychostimulant and enactogen properties

2-FMA: a halogenated analogue of methamphetamine with stimulant and possibly enactogen properties

5-IAI: an aminoindane analogue of MDAI with enactogenic properties

Methoxetamine: an arylcyclohexanamine based dissociative compound closely related to ketamine

a-PVP: an N-pyrrolidinyl derivative of the alkylphenone (substituted cathinone) family. It is an analogue of MDPV and pyrovalerone and produces stimulant effects.

Diphenylprolinol (D2MP): an atypical diphenylpyrrolidine-based stimulant with pharmacology similar to methylphenidate

Ethylphenidate: a phenylpiperidine derived stimulant closely related to methylphenidate

UR-144: an indole derived compound acting at cannabinoid sites

A Lack of Opioid RC's:

There is an exception in terms of RC availability - opioid agonists have been for the most part disregarded by commercial drug chemists. They are not available on the RC market to any significant degree, with the exception of isolated kratom alkaloids and the mild analgesic O-desmethyltramadol.

The rarity of opioids on the RC scene may indeed seem odd without further analysis of the very nature of the RC scene, and the fundamental differences between narcotic drugs and recreational or party drugs. With regard to the former, it seems apparent that the predominant consumers of the RC drugs are recreational users. Often sociable, often young and often naive in terms of drug use & degree of drug experience; such users are often intent on using research chems in a social or thrillseeking context rather than in a maintenance or self-medicating context - accounting for the popularity of the empathenogens, stimulants, cannabinoids and hallucinogens.

Another likely factor to consider is the disproportionate societal stigma of opioids at present. With a disproportionate & irrational degree of emphasis by media on prescription "heroin substitutes" and the so-called "opioid epidemic", "dope" has again become public enemy number 1 in recent years. With federal law enforcement having launched a full scale witch hunt against doctors, dealers, distributors and even medical patients. Few commercial chemists would take such a risk.

The witch hunt which would likely ensue following a single overdose - or one bizarre criminal act in which the perpetrator incidentally happens to be under the influence of an opioid RC - could very well be a death knell to the young and delicate RC industry. This is really not a matter of which drug is more dangerous or harmful, but a matter of which drug-associated incident would draw more mindless handwringing & moral panic.

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  2. "Well if we are all so f@cking worried about our "your own personal " safety. Worried that research chemicals will hurt the "ignorant" general public" . First of all opiates are not available because the so called r"Research Chemicals" have been researched ever since man could think! We only have access to it via the internet realistically for five to ten years! Cannabis is on its way to becoming accepted into society , just as sodimy was prohibited once it is now only illegal to sodamise a juvenile or the "unwilling"! So in order for our leaders to not look like a bunch of @ssholes, they need to have a new "bad guy" research chemicals! So just like alcohol,sodimy,-cannabis will be pro-choice - because there is as low of addiction potential as sodimy! The opium poppy will never be as researched as cannabis, IF THEY"GOVERNMENT" HAVE FOUND NO USE FOR IT OTHER THAN "DOPE" AFFECT AND INEVITABLY ADDICTION! THE POPPY IS SUPER CONTROLLED ITS CONTROLLED EVERYWERE! THAT MEANS ANY COUNTRY STARTS MAKING SYN. OPIUM AND SHIPPING WORLDWIDE THE "U.N" WILL SHUT -EM DOWN! ITS MY PERSONAL OPINION THAT WE SHOULD BE ABLE TO STUDY THE UNIVERSE , OURSELVES AND NOT BE JUDGED BY ANYONE OTHER THAN GOD! unless you are misusing it, or selling it as a alternative-otherwise its our own ignorance on how the whole industry is jujded , ignorance in simple words has screwed up a good thing!

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  3. I think your analysis of the lack of opioid RCs is spot on. There are a few reports out there but the potency of some of these compounds is unreal, microgram dosages. There are a few polypeptides out there that have four or five residues of the beta-endorphin sequence that can cross the BBB but the dosages are tiny and the RC vendors are scared to release them on the market. The best out there are kratom extracts but the quality really varies and I've always found that kratom leaves much to be desired...but maybe that's because my tolly is so high. Pure 7-OH-mitra would be pretty cool but I think its like more than $1000/g. Then again a 7-OH-M product on the market would probably be a fast track to the banning of kratom so maybe its for the best.

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  5. informative post keep the good work like this awaiting for a new post keep sharing.

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  6. I agree that we should sell from legal way because through this we can easily safe from those type of Chemicals which causes you death.

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  7. that the predominant consumers of the RC drugs are recreational users. Often sociable,

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  8. Research chemicals are chemical substances used by scientists for medical and scientific research purposes. One characteristic of a research chemical is that it is for laboratory research use only.
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  10. Hmm… I read blogs on a similar topic, but i never visited your blog. I added it to favorites and i’ll be your constant reader.
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  11. I agree with you, A "Research chemical" (RC) is a psychoactive drug used by scientists for medical and scientific research purposes. Now, you can buy legal research chemicals from the online store.

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