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Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Tuesday, November 8, 2011

GHB Vault


i.e. Gamma-hydroxybutyric-acid or sodium oxybate

GHB is a sedative hypnotic drug which also occurs naturally in the human central nervous system. It is used both medicinally and as a recreational drug. GHB is approved for clinical use in the US as a treatment for cataplexy associated with narcolepsy, and has been popularly termed "the date rape drug". It is sold under the trade name Xyrem.

GHB is a potent central nervous system depressant with hypnotic, amnestic, muscle relaxant, anticonvulsant, and anaesthetic properties.

It is an analogue of the inhibitory neurotransmitter GABA (chemically, gamma-aminobutyric-acid, and shares similar pharmacology. GHB acts as an agonist at the newly discovered GHB receptor, and a weak agonist at the inhibitory GABA-b receptor - The GABA-b receptor differs from the GABA-a subtype (a ligand gated ion channel), in that it is a G-protein coupled receptor.

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