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Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Wednesday, August 31, 2011

Pharmacological Targets of Psychoactive Drugs by Class



Sedative Hypnotics: CNS depressants or "downers"
GABA Receptors - agonism or postive allosteric modulation
Glutamate Receptors (NMDA, AMPA) - antagonism or blockade
Cholinergic Receptors (nicotinic or muscarinic) - antagonist or blockade

Sympathomimetics: Psychostimulants or "uppers"
Catecholamine Transporters - blockade (reuptake inhibition)
Catecholamine Transporters - phosphorylation
Catecholaminergic Neurons - increased neurotransmitter firing
Catecholaminergic Receptors - agonism or positive allosteric modulation
Note: Catecholamines include dopamine and norepinephrine.

Dissociatives: Sometimes known as dissociative anaesthetics
NMDA Receptors: antagonism or blockade
Sigma Receptors: agonism

Classical Psychedelics: Popular term being "hallucinogens"
Serotonergic Receptors (5HT2A) - partial agonism
Kappa & Delta Opioid Receptors: agonism
Cannabinoid Receptors: agonism

Deleriants: Another form of psychedelic or "hallucinogen" 
Cholinergic Receptors (nACh) - antagonism or blockade
Kappa Opioid Receptors - agonism
Histaminergic Receptors - antagonism or blockade

Opioids: Narcotic analgesics or morphinomimetics
Opioid Receptors - agonism (mu, delta, kappa, epsilon, ORL1)

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