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Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Saturday, February 26, 2011

Benzodiazepine RC's

Phenazepam

Basic:

Phenazepam is a benzodiazepine derivative with sedative-hypnotic properties. It has been sold as a research chemical, and has a reported potency of about 20x that of diazepam. 

It was developed in the 1970's and has not been used clinically in the United States. Due to its lack of popularity in the clinical setting, much if not most of the available supply of this compound is a pure powder typically sold as a research chemical. 

Use:

Phenazepam is generally taken orally or intranasally, with common doses ranging from 0.5 to 1 milligram. 

Mode of Action:

Its pharmacology is similar to other benzodiazepines; it enhances the inhibitory action of the GABA-ergic system.

Effects:

Phenazepam Structure
Its effects are similar to other benzodiazepines and can last several hours. Loss of social inhibitions and anterograde amnesia are widely reported. Users have also reported blackouts, losing track of days or weeks without recollection of this time.

Precautions:

The availability of pharmaceutical grade phenazepam preparations presents an obvious hazard for recreational users due to its potency, as the effective dosage is impossible to gauge without precision measuring equipment. Also, due to its extended elimination/half life profile, the potential for dose stacking is cause for concern. 

Legality:

Currently, phenazepam is not listed as a controlled substance in the US; as federal analog laws apply to chemicals which are substantially similar to only schedule 1 and 2 controlled substances (with benzodiazepines generally classified under schedule 4 of the controlled substance act. However, state legislation has made phenazepam illegal in Louisiana as of 2012.

Etizolam

Basic:

Etizolam Structure
Etizolam is centrally acting psychoactive compound with sedative hypnotic properties. It is a benzodiazepine derivative. 

Use:

Etizolam has been used clinically for treating symptoms of acute anxiety, agitation, and panic attacks. It has also been encountered as a research chemical for casual use. It is typically sold in the form of single dose pellets, pure powder, or as a solution.

Effects:

This drug is relatively potent as a hypnotic (i.e. sleep inducer), and is reportedly several times more potent than diazepam as an anxiolytic. 

Mode of Action:

Its pharmacology is similar to other benzodiazepines; it enhances the inhibitory action of the GABA-ergic system.

Legality:

Currently, phenazepam is not listed as a controlled substance in the US; as federal analog laws apply to chemicals which are substantially similar to only schedule 1 and 2 controlled substances (with benzodiazepines generally classified under schedule 4 of the controlled substance act.

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