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Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Monday, November 29, 2010

Warning: Avoid Injecting Fentanyl

This is extremely important so let me say this now. Transdermal patch fentanyl preparations in the GEL form (such as the original Duragesic) should NEVER be prepared for injected use; whether it's IV, IM or SC (skin popping).
The fentanyl containing gel is likely to contain an inconsistent level of fentanyl by volume, and even if the amount per gel volume is consistent, a semi-liquid substance is very difficult to divide/measure in single dose amounts in the absence of precision equipment. Secondly and less significantly (relative to a respiratory arrest and death from overdose), gel forms of fentanyl contain potentially harmful agents which should never be injected. The gel is alcohol based.

FENTANYL GEL PATCH (Trade Name DURAGESIC)
DO NOT INJECT

This is unlike the film matrix form of fentanyl, in the form of a paper thin strip: this form is designed so that fentanyl release is consistent with surface area; allowing correct *non medical* dosing to be measured by simply dividing the strip with scissors or a sharp point.

Non clinical injection of fentanyl in itself is a BAD idea, even for those who are highly tolerant. Most addicts and users alike simply do not have the knowlege or the skill (not to mention the brain) to safely use this extremely potent substance by this route.
The route with the least danger is swallowing the fentanyl orally; fentanyl is extensively metabolized when taken orally, with a bioavailability roughly in the 20 percent range. Yes this could be seen as wasteful, but I think sticking around to enjoy further fentanyl adventures takes precedence to cost effectiveness (at least to most excluding myself). A 100 microgram per hour patch contains 10mg of fentanyl; when taken orally, about 2mg (or 2000ug) will make its way to the brain. That 2mg of fentanyl is equivalent to approximately 500 MILLIGRAMS of morphine taken orally. YES, a lethal dose for any non tolerant user (this could kill you 5 times over), a possibly lethal dose for many addicts as well.

Lets take the 100ug per hour MATRIX (strip) Patch, containing a total of 10mg of fentanyl. Divide this patch evenly into 10 units to start, each unit containing 1mg (1000ug) of fentanyl. Now further dividing a unit into fourths will make dosing units of 250 micrograms: Which preferably should be divided to units of 125 micrograms, which may allow a possibly safe intravenous dose for a low-tolerant subject; equivalent to about 12.5mg IV morphine (Dividing further IS reccomended in the name of caution) Prepared into 125ug dosing units, a 100ug per hour patch will allow 40 strong injected doses. Just keep in mind, I have strongly advised against doing so, as self injecting fentanyl is extremely dangerous and kills many who attempt it. I have provided this semi-detailed information in hopes of providing guidance and harm reduction to those who are careless enough to try this.


FENTANYL TRANSDERMAL PATCH: This paper-thin matrix form can be accurately divided into smaller single dose units

Remember to start small. You can always take more. But you can never take less. One mistake with fentanyl will most likely be your last.

5 comments:

  1. Would buchal administration work better than simply swallowing the patch, similar to the administration of the actiq preperation? Perhaps a more effective method with a reduced risk profile...

    ReplyDelete
  2. umm, it can be done, and ill tell you how cause im bored and on PHP...

    1) squirt warm sterile water in between the layers of the pad. do not peal off the back! i would use 5mL first.
    2) after the water is injected, either remove the needle or pinch it between the layers while you squish the shit up. keep squishing it up for a little bit till its foamy looking.
    3) pull back the plunger on the rig and suck up all the goop. you wont get it all. take what you can and put in in a shot glass or something...
    4) repeat steps 1-3 1 more times.
    5) heat the shit up till it all ungels and looks homogeneous. suck it thru a fine filter or cotton.
    6) cook the volume down to 10mL if it isnt already.

    this means 10mg patch is now 1mg fentanyl per 1CC/mL whatever. your tolerance may vary, dose accordingly.

    i can do a 100mic patch in one shot in a 3mL rig half full..

    ReplyDelete
  3. Okay so I am just going to get down to the point.. I am a heavy opioid user/ IV. I am used to 2 40 opanas a day at least.. very heavy tolenance.. I uave only 12mg of fentanyl gel patches. Transdermal.. I know I'm going to have to do probably 2 or 3 of them but does anyone know step by step how to break it down.. and put it in a syringe for IV?

    ReplyDelete
    Replies
    1. get some fruit fresh place it in spoon or tin cup add about 50cc's of water then heat it up scrubbing the patch with a marker on the bottom of tin.be careful to not mealt the patch.just a pinch of fruit fresh will work.this is most invasive way to iv it.even thow you shouldnt

      Delete
  4. Okay so I am just going to get down to the point.. I am a heavy opioid user/ IV. I am used to 2 40 opanas a day at least.. very heavy tolenance.. I uave only 12mg of fentanyl gel patches. Transdermal.. I know I'm going to have to do probably 2 or 3 of them but does anyone know step by step how to break it down.. and put it in a syringe for IV?

    ReplyDelete