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Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Sunday, November 28, 2010

Intranasal Oxymorphone


Well, this is news to me.

Oxymorphone has been reported by studies to be rapidly and somewhat effectively absorbed by mucous membranes in the nasal passages, with an intranasal bioavailability of upwards of 40 percent (specifically 43%). Compared to its only 10 percent oral bioavailability. Important to note that overall b/a of oral formulations by this route are likely to be somewhat lower due to poor absorbtion and drug to filler ratio. An instant release nasal spray formulation of OM has supposedly been in development - I have no knowledge as to whether this is really the case.

UPDATE: See more recent post for further information

Reference:
http://pubs.acs.org/journals/jpmsae/index.html

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