Oxymorphone (or OM): Oxymorphone is related to morphine in the same fashion that oxycodone is to codeine. It is about 10 times stronger than morphine; 1mg by intravenous injection is equianalgesic to about 10mg of IV morphine. It is currently available in the US as an instant release tablet form as the brand name Opana or generic, and Opana ER; an extended release tablet form of the drug which is designed to release a steady dose over 12 hours, similar to the Oxy/MS-Contin series by Purdue. Opana ER is now available to a limited extent as a generic product marketed by Teva Pharmaceuticals.
Its high potency allows for its use in the hospital setting as a substitute for morphine; as an analgesic during minor procedures, alongside benzodiazepines or other sedatives, and as a potent, fast acting analgesic in the trauma-emergency setting. Oxymorphone is very effective for the most severe states of pain, and is generally best suited for those with a tolerance to strong opioids or an extended history of prior narcotic use. This drug generally produces desired effects with fewer adverse reactions than morphine.
Oxymorphone is relatively longer acting than similar opiates when given orally, with an elimination half life of 1 to 10 hours, and a duration of effects lasting generally no less than 6 hours. A dosing regimen of traditional oral oxymorphone may very well resemble that of agents like methadone and levorphanol more so than that of morphine and hydromorphone.
|Opana ER is a long acting oxymorphone medication|
Oxymorphone is slightly stronger than its sibling brother hydromorphone (Dilaudid) and when injected, gives an intense rush and high that is similar to hydromorphone or heroin; Some prefer its rush to either. Both oxymorphone and hydromorphone are highly regarded in the narcotic world for their heavy hitting effect when injected, and might be considered the "Holy Grail" of injected opioids in pharmaceutical form. Users afraid of needles often crush the tablets into a powder to snort, and some compare the effects to oxycodone, but cleaner or more refined. Like hydromorphone, oxymorphone may produce much less sedation or clouding than morphine. Effects are typical of an opioid agonist; possible sedation, anxiolysis, analgesia, increase in motivation or energy, positive mood change, sociability & empathy, a strong feeling of contentment and intense euphoria. These effects are pronounced when injected and remarkably subtle by other routes, with the exception of intranasal which many claim is quite intense.
Along with buprenorphine, oxymorphone has been specifically mentioned as a possible symptomatic treatment with severe depression which has not responded well to SSRI's SNRI's or stimulants. Opioids had been historically used for this purpose and are highly effective in attenuating severe depressive symptoms, much more so than today's aggressively prescribed & toxic monoaminergic antidepressants, which may be little more effective than placebo. Opioids exhibit direct action on mesolimbic dopamine transmission and profoundly alter the brain's emotional interpretation of suffering. Interestingly, research is continuously discovering connections between serotonergic transmission and the triggering of endogenous opioid transmission. Regardless of science however, the mere symptomatic treatment of mood disorders with opioids is not accepted by todays establishments, as after all, the motive behind prohibition is based heavily on social control and morality, far more than it is science. Our government is greatly concerned with protecting us from ourselves and maintaining control over individual brain chemistry and behavior, and is not open to reason.