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Providing straightforward information pertaining to drugs, drug use & drug policy. The Grey Pages promotes drug-related literacy and advocates a system of viable and tolerant drug policies. This is my personal collection of commentaries, essays, tid-bits, and other such writings on everything ranging from drug use, drug policy and drug-myths, to drug-science, addiction, human behavior, and the workings of the human brain. I started this blog with a particular focus on opioids, and over the past year have found my interest gravitate toward the intriguing, ever-changing world of designer intoxicants (i.e. "research chemicals" or "designer drugs").

Monday, October 18, 2010

PCP Receptor Defined

PCP1 Receptor (NMDA Complex):

Located on the interior surface of the NMDA ion channel complex. PCP, ketamine, and DXM act at this site to block the ion channel of the NMDA complex (i.e. NMDA antagonism).

PCP2 Receptor (Dopamine Reuptake Complex):

The PCP2 receptor for (named after the drug PCP), is located on dopamine reuptake complexes. It is targeted by PCP and dextromethorphan. The action of these drugs at the PCP2 site modulates an increase in mesolimbic dopaminergic tone (by inhibiting the function of the reuptake transporter).

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