PCP1 Receptor (NMDA Complex):
Located on the interior surface of the NMDA ion channel complex. PCP, ketamine, and DXM act at this site to block the ion channel of the NMDA complex (i.e. NMDA antagonism).
PCP2 Receptor (Dopamine Reuptake Complex):
The PCP2 receptor for (named after the drug PCP), is located on dopamine reuptake complexes. It is targeted by PCP and dextromethorphan. The action of these drugs at the PCP2 site modulates an increase in mesolimbic dopaminergic tone (by inhibiting the function of the reuptake transporter).